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NRF2 regulates mitochondrial redox homeostasis by several mechanisms such as detoxification of peroxides, regeneration of GSH, increased synthesis of GSH and NADPH and via the NRF2-Keap 1 response

The peptide powerfully modulates inflammation by increasing microRNA-146a expression while decreasing pro-inflammatory cytokines including TNF-alpha, IL-6, IRAK1, and TRAF6

Tetrahedron 2022, 127, 133095

Charpentier, E

In research protocols, this can be either desirable (for models examining appetite regulation, weight gain, or catabolic disease states) or undesirable (for protocols where appetite stimulation is a confounder)

PLoS ONE 10 , e0138904 (2015)