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The existence of such a reservoir provides a plausible mechanism for how oxidative metabolism could proceed briskly in the parenchyma without being immediately reflected in vascular oxygen measurements (Schurr, 2025)

The final covariate models for subject ( i ) and dosing occasion ( j ) were parameterised as follows: where In the above equations, is the estimated (or fixed) value for each covariate, ka.long.fast is the absorption rate constant for fasting times of 120 min or longer, i is the subject-level random effects, j is the occasion-level random effects

Researchers should account for this when designing protocols that measure activity levels or energy expenditure

Medicina 55, 72

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