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Indeed microglia were found to be critical to glioma development 98 and macrophages are abundant in neurofibromas and MPNSTs

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On the other hand, cellular effects, which are fundamentally significant for regenerative medicine, are revealed only indirectly

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DR results from high levels of glucose, and an increase flux through the HBP, leading to higher levels of UDP-GlcNAc, which in turn increase O -GlcNAc modification resulting in altered cellular functions, especially in pericytes (63)

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