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If you start with a peptide that is underdosed, full of synthesis impurities, or improperly lyophilized, no amount of perfect technique can save it

doi: 10.3389/fbioe.2020.570828 Received 09 June 2020 Accepted 15 September 2020 Published 12 November 2020 Volume 8 - 2020 Edited by Chettiyappan Visvanathan, Asian Institute of Technology, Thailand Reviewed by Xiaowei Li, Chalmers University of Technology, Sweden

Rajasekaran NS, Connell P, Christians ES, Yan LJ, Taylor RP, Orosz A, Zhang XQ, Stevenson TJ, Peshock RM, Leopold JA, Barry WH, Loscalzo J, Odelberg SJ, and Benjamin IJ

Research-grade glutathione is used to study oxidative stress and antioxidant defense, ferroptosis and lipid peroxidation (via GPx4), xenobiotic detoxification, the Nrf2/HO-1 cytoprotective pathway, and redox involvement in models of aging and neurodegeneration

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Full radioprotection would yield a signal for 15 Gy+drug that was statistically equivalent to the 0 Gy control, or a recovery of 100%