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Am J Physiol Endocrinol Metab 281:E1340-1346
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No research program is without constraints, and acknowledging these limitations helps set appropriate expectations

While theres the promise, 5-Amino-1MQ research is in its infancy

However, it is noteworthy that ten oligonucleotide drugs have been officially approved by FDA as of January 2020 [55], which means that the technological obstacles for oligonucleotide therapeutics are being solved step by step and the development of oligonucleotide drugs targeting NNMT is still a promising method for the prevention or treatment of obesity and related T2D in the future

The second category included substances considered too risky for compounding
