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Characterized by iron toxicity accumulation, phospholipid peroxidation and dysfunctional mitochondria, ferroptosis is intricately linked to the hepatic microenvironment, influencing and being influenced by factors such as iron homeostasis, glucose metabolism, lipid metabolism, amino acid metabolism, and the gut-liver axis

The presence of melatonin in these organelles is likely of special importance when there is a rapid deluge of newly produced radicals such as occurs during exposure to ionizing radiation (94), injurious chemicals such as paraquat (95), or toxic drugs such as including chemotherapies (96)

Sui M, Jiang X, Chen J, Yang H, Zhu Y

Drugs 81 , 277282 (2021)

10.1093/annonc/mdh398 [DOI] [PubMed] [Google Scholar] Erratum: Global cancer statistics (2020)

FIGURE 3 Furthermore, a thorough mutagenesis study of Md ACO1, identified other important residues essential for ACO activity: C28, T157, K158, R175, Q188, K199, K230, R244, S246, K292, E294, E297, R299, F300, and E301 (Dilley et al., 2013)