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However, excess cellular iron is toxic, resulting in hydroxyl radical production via the Fenton reaction

[Experimental study of the effects of metabolic drugs on exercise tolerance]

Oxidative stress and NLRP3 inflammasome activation could also be triggered by TMAO, whereat inflammatory cytokines such as IL-18 and IL-1 were increased released (Sun et al., 2016

Finally, Villardita et al 36 evaluated ALC versus placebo, but did not report depressive-symptom efficacy results in a way that could be summarized quantitatively

10.1161/ATVBAHA.118.311023 15

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