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The figure describes an in-vitro dendritic-spine assay in which picomolar Dihexa produced spine density comparable to nanomolar BDNF a potency ratio in a specific cell-culture readout

Conditions like Crohns disease, celiac disease, or those who have had surgery on the digestive tract may have difficulty absorbing B12

This paper 11/hex.13152 shows just how many people feel about their interactions with their doctor regarding B12 deficiency Response from NICE: NICE does not generally include dosages in recommendations where they are available in the BNF or SPC

dose is individualized based on indication and response Frequency Once or twice daily

But can we directly link vitamin B12 deficiency and weight gain and loss

In some people this manifests as diarrhea, in others constipation