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Thioredoxin-1 decreases alpha-synuclein induced by MPTP through promoting autophagy-lysosome pathway
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[1] Disturbances in the normal redox state of cells can cause toxic effects through the production of peroxides and free radicals that damage all components of the cell, including proteins, lipids, and DNA

10.1007/s11099-007-0062-9 Photosynthetica 16 EltayebA

Chronic fatigue syndrome (CFS) reflects an energy crisis in the body that triggers a host of downstream effects such as muscle pain, insomnia, hormonal deficiencies, infections, poor liver detoxification, immune dysfunction, and decreased heart function

Whatever the mechanism may be, it is widely accepted that normal mitochondrial respiratory activity and oxidative metabolic capacity are important for modulating oxidative stress