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52, 53, 54, 55, 56 Conversely, when the CDDP-induced DNA damage is irreparable, either such a cell cycle arrest becomes permanent (an oncosuppressive response known as cellular senescence) 57, 58 or cells become committed to die, most often via mitochondrial apoptosis
This meant that there was a large therapeutic window, and a wide range of the agents efficacy (gng), at any stage of the noxious course

Reactive oxygen species and antitumor immunity-from surveillance to evasion

Plos One 18 (1), e0280548

Yes glutathione reduces melanin production by blocking the tyrosinase enzyme

J Eur Acad Dermatol Venereol 30(2):223249
