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Description
Both UK-5099 and -cyano-4-hydroxy cinnamate have been reported to also inhibit the monocarboxylate transporters found at the plasma membrane and therefore potentially cellular pyruvate uptake

Unfortunately, with about 3,100 known causative mutations in over 50 different genes, each gene target would require a unique treatment [4]

[2] Ji Y, Azuine RE, Zhang Y, Hou W, Hong X, Wang G, et al

Methemoglobinemia, or an elevation of oxidized hemoglobin called methemoglobin, can also develop in patients with G6PD deficiency following an increase in oxidative stress

FDA-approved options like semaglutide (Wegovy) and tirzepatide (Zepbound) have decades of clinical outcome data behind them

doi: 10.1152/physrev.00042.2007
