Frontiers
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Description
DNA hypomethylation of TXNIP has been shown to promote the elevation of inflammatory biomarkers, including VCAM-1 , ICAM-1 , MMP-2 , sRAGE , and P-selectin (Xiang et al., 2021), while chronic increases in these biomarkers can impaire the signaling pathways necessary for pericyte survival ( TXNIP levels, and ultimately resulted in pyroptosis in RPE cells
Robillard et al., 2016)
The following sections detail the interconnected mechanisms underlying NO-induced neurotoxicity
Medical background recommended
doi: 10.2478/prolas-2020-0050 146 SasidharanR.Bailey-SerresJ.AshikariM.AtwellB
doi:10.1093/jn/123.9.1554
