glutathione levels in human tumors Involvement of peroxidases the occurrence and development of breast cancers | Journal of Translational Medicine Glutathione-Dependent Pathways in Cancer Cells

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Similar to free drug combinations, 2/1PHPPMs with a loaded drug mass ratio (PTX/HK) of 2:1 showed the highest cytotoxicity (lowest IC 50 value) and the best synergistic effect (lowest CI 50 value) (Figures 5F,G), suggesting that the optimal drug combinations dose for cocktail PPMs can be easily screened using free drugs

The ethenoacetaldehyde adducts also retain the BDAcarbon atoms (Byrns et al., 2004, 2006)

[DOI] [PubMed] [Google Scholar] 103.Zheng L., Wang H., Ba Y.-Y., et al

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Mitochondrial dysfunction As a dynamic biophysical system, mitochondria play a major role in regulating energy metabolism and dominating cell death or survival