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Jin Q, Yao C, Bian Y, Pi J

Low levels of glutathione have been associated with various health issues, including chronic diseases and even accelerated aging

[DOI] [PMC free article] [PubMed] [Google Scholar] 13.Park M.W., Cha H.W., Kim J., Kim J.H., Yang H., Yoon S., Boonpraman N., Yi S.S., Yoo I.D., Moon J.S

Previous studies reported that the presence of curcuminoids is associated with anti-inflammatory capacity, which is attributed to a reduction in lipid peroxidation, inhibition of the binding of the transcription factor NF-B (nuclear factor kappa B) to DNA, leading to a decrease in pro-inflammatory cytokine concentrations, as well as a reduction in circulating inflammatory levels of gamma interferon and inhibition of COX-1 (cyclooxygenase-1 enzyme), COX-2 (cyclooxygenase-2 enzyme), and LOX activities (7, 13, 53, 58)

for instance, the exact cellular localization of Scly, whether Scly directly transfers Se to selenophosphate synthetase 2 (SEPH2) or there are other proteins involved, and the exact role of minor intermediates such as selenohomocysteine (trans-selenation pathway) or Se bound to glutathione (selenite reduction pathway) in Se turnover (Seale et al., 2018a