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Patients were randomized to receive pemetrexed 500 mg/m2 intravenously every 21 days or placebo until disease progression

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The accumulation of misfolded protein in the endoplasmic reticulum (ER) leads to ER dysfunction, which is known as ER stress ( 12 regulated ER homeostasis ( 12 deficiency activated ER stress pathways by increasing the phosphorylation of PERK and IRE1 and the expression of ATF6 ( 12 could promote nerve regeneration after TBI by regulating ER stress

Some peptides with hydrophobic domains may require initial dissolution in a dilute acetic acid solution before being diluted with bacteriostatic water

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