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Chronic ascorbic acid administration (1 mg/kg, gavage, 21 d) produces an antidepressant-like effect in the mouse [27] and ameliorates behavioral despair induced by tumor necrosis factor [28]

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The quercetin molecule has a variety of biological activities and pharmacological effects due to its four phenolic hydroxyl groups, one enolic hydroxyl group, and one carbonyl structure

Global analysis of L1-transcriptomes identified IGFBP-2 as a target of ezrin and NF-B signaling that promotes colon cancer progression

However, with age, autophagy becomes less efficient, leaving behind resistant senescent cells that drive organ degeneration

Post-mortem studies and patient-derived models consistently show features of mitochondrial dysfunction, such as swelling, fragmentation, and vacuolization, particularly in motor neurons [197,198,199,200]