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Pharmacol Res 155:104730 Salminen A, Kaarniranta K, Kauppinen A (2013) Crosstalk between oxidative stress and SIRT1: impact on the aging process

doi: 10.1016/j.immuni.2010.05.007 31 WuMSongDLiHYangYMaXDengSet al

Paeonol inhibits ACSL4 to protect chondrocytes from ferroptosis and ameliorates osteoarthritis progression

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Enzymatic defenders form a formidable internal defense against the onslaught of oxidation, but this natural protective mechanism can be disrupted by the increasingly common factors of poor dietary choices, pollution, stress, and overuse of antibiotics, leading to a diminished capacity to fend off oxidative damage

Walker et al