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Description
Materials and methods

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Immune checkpoint inhibitors (ICI): a single case report showed that combined therapy (L-carnitine + pembrolizumab

The possible mechanisms that account for the beneficial response seen with L-carnitine in AMI are probably multifactorial and include, in part, an improvement in myocardial mitochondrial energy metabolism in the heart due to its ability to enhance the transport of long-chain fatty acids from the cytosol to the mitochondrial matrix where -oxidation occurs, removing toxic fatty acid intermediates, lessening ischemia secondary to elevated long-chain fatty acid concentrations, and replenishing the depleted carnitine concentrations seen in ischemic, infarct, and failing myocardium

doi: 10.3390/molecules24183247

PMID: 37979236 This page explains the treatment and management of Systemic Primary Carnitine Deficiency for educational purposes only
