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doi: 10.3390/biology12020279, 35
This product is supplied as a high-purity synthetic peptide intended strictly for laboratory and research applications
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The first step of SSP is catalyzed by phosphoglycerate dehydrogenase (PHGDH), which converts 3-phosphoglycerate (3-PG), derived from glucose, into 3-phosphohydroxypyruvate (3-PHP) with concomitant reduction of NAD + to NADH ( D -2HG within the cellular milieu ( PHGDH impairment has broad metabolic consequences, affecting serine availability, the TCA cycle anaplerosis, redox balance, energy metabolism, nutrient sensing, and cell signaling ( D -isomer metabolites
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