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HO-2 and HO-3 are the constitutive isoforms responsible for the majority of HO activity, whereas HO-1 expression is primarily induced by its physiological substrate, heme, or various external stimuli (Ryter et al., 2006)

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Hypertension Hypertension is a well-established independent risk factor that predisposes individuals to fatal complications in CVDs

[DOI] [PubMed] [Google Scholar] 149.Cai Y., Yu S.S., He Y., Bi X.Y., Gao S., Yan T.D., Liu P.Q

Smoking also contributes to skin ageing and may lead to early signs of ageing, such as wrinkles, fine lines, and discoloration

A person with pernicious anemia requires lifelong vitamin B12 supplementation
