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In a first-in-human clinical trial (NCT02491281), LNA043 was administered via intra-articular injection before total knee replacement, and results showed that LNA043 could reverse the transcriptome signature associated with osteoarthritis by promoting the expression of hyaline cartilage matrix components and anabolic signaling pathways [435]

The AIs for infants and children were calculated by extrapolation from the AI for adults

The central compartment volume is approximately 2.47 liters per 70 kilograms of body weight

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Retrieved 2021-10-13

Evidence: Well-validated across many injury types