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Description
The extrinsic pathway involves the activation of a protease cascade intitated by the activation of caspase 8 through the action of death receptors and their ligands, for example, FasL, and tumor necrosis factor- (181)
No lethal dose was established, suggesting a wide safety margin

168 This strategy exploits the acidic pH of the tumor milieu to enable selective insertion and delivery, thereby enhancing targeting precision

The data are pretty cool

It is also used to boost immune function and to decrease memory loss

Heres the scientific bottleneck: human evidence remains extremely thin
