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Access options Access Nature and 54 other Nature Portfolio journals Get Nature+, our best-value online-access subscription 27,99 / 30 days cancel any time Subscribe to this journal Receive 52 print issues and online access 196,21 per year only 3,77 per issue Rent or buy this article Prices vary by article type from$1.95 to$39.95 Prices may be subject to local taxes which are calculated during checkout Nature 641 , 1086-1088 (2025) doi: Updates & Corrections Correction 04 June 2025 : An earlier version of this story mistakenly stated that cells direct therapeutic IDS to the lysosome as waste

A-syn and early synaptic dysfunction Evidence from both human and animal models has demonstrated that before clear signs of neurodegeneration appear in specific brain regions, other dysfunctions occur in the same neuronal circuits at a synaptic level in apparently intact cells
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A total of 46 healthy female individuals aged 4569 years were enrolled and divided into the placebo group ( n = 23) or treatment group ( n = 23), which ingested one capsule of 500 mg of hydrolyzed fish cartilage, once a day, every night for 90 days

