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Thorarensen, S

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A key challenge arises from the cysteine residue, which is prone to heterogeneous post-translational modifications of the thiol group that result in multiple unknown isoforms, effectively diluting an already low-density target 17
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Justin Watts MD, Anthony Hunter MD, Alessandra Iurlo MD, PhD, Blanca Xicoy MD, Francesca Palandri MD, PhD, Brandi Reeves MD, Alessandro Vannucchi MD, Prithviraj Bose MD , Rosa Diaz MD , Anna Halpern MD, PhD XC, Lea Burke MS, PhD FZ, Fred Zheng MD, Pankit Vachhani MD

Side effects are uncommon and usually mild, like brief soreness at the injection site