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During lens differentiation, crystallin levels are highly upregulated, while degradation of organelles such as nuclei, mitochondria, endoplasmic reticulum, and ribosomes occurs (148)

Ivaska, J., Whelan, R

Metformin may increase the risk of lactic acidosis, so starting the treatment with this agent needs to be preceded by careful analysis of renal, liver or heart function of the patient

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