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223 HIF-1 plays a pivotal role in the metabolic shift to aerobic glycolysis, known as the Warburg effect, facilitating glucose conversion to lactate despite sufficient oxygen availability

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Upon tumor necrosis factor-alpha (TNF-) stimulation, TNFR1 undergoes a conformational change that facilitates the recruitment of several adaptor proteins to form membrane-bound signaling complex I, consisting of TNFR1-associated death domain protein (TRADD), RIPK1, TNF receptorassociated factor 2 (TRAF2), and the cellular inhibitors of apoptosis (cIAP1/2) to form membrane-associated complex I (14)

Estimated enrollment is 40 patients

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