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Histamine Promotes the Release of Interleukin-6 via the H1R/p38 and NF-kappaB Pathways in Nasal Fibroblasts

[DOI] [PMC free article] [PubMed] [Google Scholar] 53.Jackson A

Mitochondrial dysfunction associated with A and tau pathology in AD includes decreased ATP production, mitophagy, biogenesis (decreased expression of peroxisome proliferator-activated receptor gamma coactivator 1-alpha, PGC-1), activity of components of the OXPHOS system and other enzymes (e.g., 17-hydroxysteroid dehydrogenase type 10, HSD-10), mitochondrial membrane potential ( m ), and import of mitochondrial proteins, imbalance of mitochondrial dynamics (upregulation of dynamin-like protein-1, DRP-1), impairment of intracellular Ca 2+ homeostasis, membrane damage, interaction with adenine nucleotide translocator 1 (ANT1) and voltage-dependent anion channel 1 (VDAC1), and increased ROS production, apoptosis (increased cytochrome c release), and mPTP opening [8,63,68,72,73,74] (Figure 2)

The MS 2 spectra of TFA-cleaved peptide showed complete mapping of the expected product [164]

In the 1980s, when the work on gastric juices began, funding for Croatian scientists was limited, Sikiric said, and there were few opportunities to engage with Western researchers

Rabe, C., Steenkamp, J.A., Joubert, E., Burger, J.F.W., Ferreira, D