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(Nature, 2014) used an antisense oligonucleotide to knock down NNMT in mice and reported reduced fat-mass gain, better glucose tolerance, and lower liver triglycerides the founding paper for the whole NNMT-inhibitor field

Reduced appetite and better blood sugar control: According to the supplement descriptions, taking 5-Amino-1MQ is associated with reduced hunger and stabilised blood glucose levels

[DOI] [PubMed] [Google Scholar] 80.Ilic S., Drmic D., Zarkovic K., Kolenc D., Brcic L., Radic B., Djuzel V., Blagaic A.B., Romic Z., Dzidic S., et al

The fat loss was visually obvious and confirmed by tissue analysis

Over time, adding strength training such as weightlifting, yoga, or bodyweight exercises builds lean muscle, which increases metabolism and helps sustain weight loss

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