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These include: Social communication/interaction differences (all three required): Deficits in social-emotional reciprocity Deficits in nonverbal communicative behaviors Difficulties developing, maintaining, or understanding relationships Restricted/repetitive patterns (two or more required): Stereotyped/repetitive movements or speech Insistence on sameness or inflexible routines Highly restricted, fixated interests Hyper-/hyporeactivity to sensory input Symptoms present early in development (though may be masked until later)

47 : 204 - 213 Lourenco R, Camilo ME

What It Targets Our GHK-Cu topical peptide is designed to target: Fine lines (crows feet, smile lines) and early wrinkles needing gentle, consistent softening. Mild to moderate laxity, crepiness, and loss of firmness in the face, neck, or dcollet. Photodamagedull tone, uneven texture, mottled pigmentation, and residual sun spots. Posttreatment skin (microneedling, peels, laser) that needs accelerated repair and reduced downtime. Benefits Topical GHK-Cu is believed to help with: Collagen + elastin boost: GHKCu cream has been shown to increase collagen I and III, dermal thickness, and elasticity, with clinical trials reporting up to ~3055% reductions in wrinkle volume and meaningful improvements versus retinoic acid or vitamin C in some studies. Barrier repair and calming: Copper peptides help restore barrier proteins and lipids, reducing redness, irritation, and dehydration while protecting skin from oxidative and inflammatory damage. Texture and tone refinement: Regular use smooths rough patches, softens acne marks, and helps lighten mottled hyperpigmentation and sun damage for a more even, luminous tone. Postprocedure friendly: Compared with many acids or strong retinoids, GHKCu is better tolerated and frequently used to speed healing and results after microneedling, laser, and RF, making it a perfect Better Med Spa addon.

doi: 10.1016/S0140-6736(13)60096-3

Face and neck Facial skin serves as the primary application area for most copper peptide users

At Refine by Tulsi, all NAD+ IV and injection protocols are physician-supervised