melanotic definition Labial macule Melanotic macule. Benign. Dark spot

This effect occurs independently of UV radiation exposure, making MT-II relevant in research examining UV-independent tanning mechanisms, photo-protection, and the role of melanin in shielding skin from UV-induced DNA damage

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The Nrf2 pathway is typically induced in response to oxidative stress, inflammation, and other cellular stressors [77]

While benign LM typically demonstrates stable, homogeneous and orderly patterns, NUM is characterised by asymmetry, irregularity and progressive evolution