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However, the labelling (M + 4) in metabolites produced after direct metabolism of [U- 13 C] glutamate such as fumarate, malate and aspartate was significantly decreased in FTD3 neurons compared to isogenic controls (with the exception of fumarate and -kg M + 4 in H150, Fig 3 c 25 ), in contrast to the first turn TCA cycle in which metabolites were unmodified in FTD3 neurons compared with isogenic controls

2016a , 2016b )

Experiments were analyzed in a blinded manner and all behavioural tests were independently replicated at least once

The confusion stems from the assumption that all metabolic peptides compete for similar pathways
