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Figs.1 and 2 were created with BioRender.com Author Contributions Anastasiia Badaeva conducted the primary research and drafted the initial manuscript Alexey Danilov, Anastasiia Kosareva, Mariia Lepshina, Yulia Vorobyeva, Viacheslav Novikov, Andrey Danilov contributed to the reviewing and critical revision of the manuscript

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Cases diagnosed with dysplasia or melanoma require appropriate treatment [Figure 6]

Epac2 induces synapse remodeling and depression and its disease-associated forms alter spines

We have proposed that energy is transduced through a mechanical coupling between the inner and outer membrane complexes, supported by simulations that demonstrate the strength of the TonB-transporter connection mediated by hydrogen bonds, as well as the response of the transporter to the application of force