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Monitoring is reasonable

Inclusion criteria: all participants must: be 65 years of age be attending a primary healthcare centre for consultation on some medical matter provide their informed consent to be included have a serum B12 concentration of 200 pg/ml at 4 months in over 70% of patients

Avoid Over-Dilution: Adding too much water (e.g., 10 mL to a 2 mg vial) results in a dilute solution, requiring larger injection volumes that may be impractical or uncomfortable

35 There is also compelling evidence that vitamin B 12 deficiency occurs frequently during pregnancy, 2 6 7 and case studies have demonstrated harmful effects of severe vitamin B 12 deficiency on the developing infant brain

Pingitore, A

Diagnosis is made by collagen typing in a skin biopsy