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Increased root canal endotoxin levels are associated with chronic apical periodontitis, increased oxidative and nitrosative stress, major depression, severity of depression, and a lowered quality of life

Corticosteroids and antioxidants can work synergistically: the former reduces the airway pro-oxidative state [4] and the latter restores optimal glucocorticoid sensitivity [5,42] to reduce bronchial hyperresponsiveness, increase asthma control, and preserve lung function

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