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PINK1 or PARK2-mediated mitophagy loss significantly increases the production of mitochondrial reactive oxygen species (mROS) and amplifies the transforming growth factor (TGF)-1/Smad2/3 cascade, thereby accelerating renal fibrosis (Li 2020)
doi: 10.1016/s0891-5849(03)00388-5
Murray MM, Imber ML, Savitt DC, Foxe JJ (2006)
Are B12 shots better than pills
Cerebrolysin studies suggest 10mL minimum per infusion for neurological benefits, lower doses ineffective
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