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Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated

Therapeutic targeting of proteostasis in cancer Cancer cells are exposed to persistent proteotoxic stress driven by rapid proliferation, genomic instability, hypoxia, metabolic rewiring, and therapeutic pressure

Nov 2021 Frontiers Media S A Peng, C., Chen, Y., & Jiang, M

Our data showed that, unlike phentermine, tesofensine at 2 mg/kg induced few, if any, head weaving stereotypy ( Fig 7C )

R., Dringen R., and Bishop G

Paradoxically, while normal prostate physiology prioritizes polyamine synthesis (e.g., spermine), regulated by androgen-dependent enzymes like ODC to support secretory functions, PCa progression exhibits a contradictory polyamine landscape: spermine levels decline sharply despite ODC overexpression, a phenomenon contrasting with polyamine accumulation patterns in other cancers