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(LEA / EHMC) 50:12 Replacement dose vs PED 55:47 Four takeaways 57:46 Episode 4 preview and book pre-order What we cover: How body fat suppresses testosterone at two different points in the HPG axis, and why the loop is self-reinforcing The leptin and Kisspeptin pathway most clinics never address Marks case: a 45-year-old with a 240 ng/dL afternoon draw, no workup, and an immediate prescription Primary versus secondary causes, and why Klinefelter syndrome is the under-recognized one to not miss Weight loss dose-response: how much testosterone climbs on lifestyle alone, with GLP-1 agonists, and after bariatric surgery T4DM: why adding testosterone to a structured weight-loss program produced no extra quality-of-life benefit over placebo One week of sleep restriction drops testosterone by about 15 percent in healthy young men

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This substitution may increase the half-life of the peptide by protecting it from enzymatic cleavage and degradation