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neuropathy), effective replacement therapy should lead to a normal full blood count and B12 level after 8 weeks of treatment, while improvement in neurological symptoms begins very quickly within one week of initiation of therapy but can take up to 3 months to resolve (Carmel, 2008)

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This interplay between inflammation, OS, insulin resistance, and hyperglycemia perpetuates a detrimental cycle, elevating the risk of diabetesrelated complications 4 (Figure 1)

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and provide antioxidant protection by scavenging ROS and upregulating Nrf2-dependent antioxidant enzymes (59, 60, 7981)

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[DOI] [PMC free article] [PubMed] [Google Scholar] 72.Segawa H., Fukasawa Y., Miyamoto K., Takeda E., Endou H., Kanai Y

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The authors also suggest that taurine could bind Zn 2+ under physiological conditions [271]

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