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In this study, we found that LOsG treatment elevated the protein levels of TGF1, p-SMAD3, and SMAD4 in rat pancreas

Apr 2017;45(2):147-155

doi: 10.1007/978-94-007-4525-4_13 Summary Keywords pneumococcal meningitis, vitamin B12, epidrugs, neuroinflammation, histone methylation, neuroprotection Citation Cassiano LMG, Oliveira MS, de Queiroz KB, Amancio AMTS, Salim ACM, Fernandes GR, Carneiro CM and Coimbra RS (2023) Uncovering the neuroprotective effect of vitamin B12 in pneumococcal meningitis: insights into its pleiotropic mode of action at the transcriptional level

demonstrated that knockdown of the Nmnat1 gene in hepatic cells leads to depletion of nuclear NAD + , thereby causing mitochondrial dysfunction ( + salvage pathway