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In the retina, CYP epoxygenases generate arachidonic-acidderived epoxyeicosatrienoic acids (EETs) that are vasodilatory in systemic vessels yet, under diabetic and hypoxic retinal conditions, can potentiate VEGF signaling, angiogenesis, and vascular leak (56)

doi: 10.1016/j.nut.2021.111169

An adenovirus carrying ferritin light chain/heavy chain and transferrin can up-regulate NF-B/INOS and down-regulate Nrf2/GPX4 in the ovaries of 3-month-old rats, confirming that oxidative stress-inflammatory response is mediated by iron homeostasis disorder in ovarian aging

PMC 8300930

Oxidative stress also drives chronic inflammation and disease progression in the airways by activating intracellular signalling pathways and the release of further inflammatory mediators

ROS and calcium also act in the correct communication between mitochondria and ER, which is key to maintaining the correct homeostasis in renal cells, especially in the proximal tubule