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All reduced aggregation of the respective point-mutant target, with several identified to be effective at reducing aggregation and toxicity in an SH-SY5Y line when incubated with other variants

These findings tightly link ROS and Nrf2 to ER oxidative protein folding and calcium signaling, establishing a regulatory mechanism for protein oxidative folding-Nrf2-ER calcium axis (Figure 7)

Cancer 13 , 669680 (2022)

We next focused on astrocytes, important integrators of both neuronal activity and inflammatory signaling

This study provides important clues for the study of the pathogenesis of NSCLC and lays a solid foundation for the search for precision treatment targets and effective therapeutic drugs for this disease

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