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The chemopreventive efficacy of various phytochemicals that has been demonstrated in cell models frequently cannot be extrapolated to whole organisms due to low bioavailability

12 WrightJWHardingJW

doi: 10.1038/s42255-020-00280-9 33 DelgoffeGMPowellJD

In a rat model of IR injury, the nanotherapeutic was efficiently delivered to inflamed cardiomyocytes via PGE2-mediated transport

Activation of SERM -ER in the brain causes detachment from the last HSP70 proteins, which ensures the entry of these proteins into the cell and the implementation of their biological function

Common research dosages range from 1-10 mg/kg in preclinical studies