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TGF-1 induces HIF-1 overexpression and nuclear accumulation by upregulating NOX4 expression and ROS production, ultimately leading to metabolic reprogramming and promoting EMT

In addition, when CNS insulin signaling is inhibited by antibodies to insulin or by inhibitors of insulin receptor signaling molecules, systemic insulin fails to suppress hepatic endogenous glucose production

Jacobs DE, Clickner RP, Zhou JY, Viet SM, Marker DA, Rogers JW, Zeldin DC, Broene P, Friedman W (2002) The prevalence of lead-based paint hazards in US housing

Association between glutamate transporter gene polymorphisms and obsessive-compulsive disorder/trait empathy in a Korean population

Therefore, we hypothesized that irreversible covalent modification of GPX4 by DAQ may alter its function, and, subsequently, activate the ferroptotic pathway, to modulate dopaminergic neuron degeneration

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