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Alternatively, these molecules elicit cellular responses leading to the chemical modification of other molecules either resident or transported into the LROs

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LPPtiger 2.0 is a cross platform (Linux, macOS, and Windows) open-source software released under AGPL license for academic users, the source code and executable files for Windows platform are freely available on GitHub repository: For manual control of identification accuracy, and for detailed assignment of modification type- and position-specific fragment ion signals, lists of in silico oxidized lipids generated by LPPtiger 2.0 with possible precursor-oxidized fatty acid (oxFA) fragment pairs as well as fragmentation rules defined for the in vitro oxidized standards (Supplementary Data 2) were used as a support

While glucose, glutamine, and amino acids are well-recognized as critical energy sources and carbon donors during immune activation, the contribution of choline, a vitamin-like metabolite, has been overlooked