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This persistent inflammation is driven by a "cytokine storm" effect, where pro-inflammatory molecules like Interleukin-6 (IL-6) and Tumor Necrosis Factor-alpha (TNF-) remain elevated, causing widespread damage to the endothelium (blood vessel linings), muscles, and joints

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This metabolic reprogramming is associated with exacerbated oxidative stress, neuroinflammation, and accelerated pathological progression

Cai Y, Lydic TA, Turkette T, Reid GE, Olson LK (2015) Impact of alogliptin and pioglitazone on lipid metabolism in islets of prediabetic and diabetic Zucker Diabetic Fatty rats

Effects of forced diving on the spleen and hepatic sinus in northern elephant seal pups

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