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Moreover, the epigenetic modifier enhancer of zeste homolog (EZH2) overexpression in breast cancer results in the trimethylation of histone H3 at lysine 27 (H3K27me3), a process that occurs at the promoter of programmed death ligand 1 (PD-L1) and causes the inhibition of the immune response-related genes and the enhancement of drug resistance and metastatic capacity (Y

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The first study of a blocking antibody to IL-5 showed a marked reduction in circulating and sputum eosinophils but no change in the response to allergen or in airway hyperresponsiveness, raising doubts about the role of eosinophils in asthma

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