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In various PD models, including toxin-induced and inherited forms in mice, rats, fruit flies, and induced pluripotent stem cells, TZ increases brain ATP levels, slowing or preventing neuronal loss
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A revised reference list of genotoxic and non-genotoxic chemicals recommended for assessing the performance of new or improved in vitro genotoxicity test methods has been developed to fit the following different sets of characteristics (Kirkland et al., 2016): Group 1: Chemicals that should be detected as positive in in vitro mammalian cell genotoxicity tests
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Deep mutational scanning, cryo-electron microscopy (cryo-EM) and intact-mass spectrometry (MS) reveal covalent engagement of DCAF16 via cysteine 173
