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Acneiform or skin changes have been reported with high-dose or frequent B12 administration, though the mechanism remains unclear

All tests were performed using an Olympus AU2700 analyzer with original test reagents (Olympus Diagnostics, Ireland) [24]

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Vitamin B12 (cobalamin) is a watersoluble vitamin essential to multiple cellular processes including hematologic function, methylation pathways, nervous system signaling, and energy metabolism