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Neurobiol Dis 81:93107

pointed that SIRT1 activation may mediate the upregulation of GPX4 levels by Nrf2-HO-1 axis in the alleviation of neuronal injury

Additionally, photosynthetic eukaryotes generate oxygen as a byproduct of photo-synthesis that is converted to toxic metabolites under abiotic stress conditions which could damage biomolecules of the photosynthetic apparatus