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106 Independent of the exact molecular mechanism, ferrostatin-1 has low bioavailability, a short half-life in vivo , and limited microsomal and plasma stability

Pain can come on suddenly or develop over time

Mild to moderate nausea following an accidental overdose, while unpleasant, is usually self-limiting

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The functional implication is a systems-level weakening of cohesion maintenance and checkpoint surveillance, providing a mechanistic bridge between transcriptomic shifts and the higher incidence of aneuploidy and reduced developmental competence observed with reproductive aging [110,111,112]